Decreased β-Amyloid1-42and Increased Tau Levels in Cerebrospinal Fluid of Patients With Alzheimer Disease
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چکیده
منابع مشابه
Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients.
The amyloid beta-protein is deposited in senile plaques and the cerebrovasculature in Alzheimer disease (AD). Since it is derived from proteolytic processing of its parent protein, the amyloid beta-protein precursor (APP), we investigated whether levels of the secreted forms of APP are altered in cerebrospinal fluid (CSF) of AD patients. Quantitative immunoblotting studies with the anti-APP mon...
متن کاملDifferential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231.
BACKGROUND Phosphorylation of tau protein at threonine 231 (using full-length tau, 441 amino acids, for the numbering scheme) (p-tau(231)) occurs specifically in postmortem brain tissue of patients with Alzheimer disease (AD) and can be sensitively detected in cerebrospinal fluid (CSF). OBJECTIVES To determine to what extent CSF levels of p-tau(231) distinguish patients with AD from control s...
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Background: Behçet's disease (BD) is a systemic inflammatory disease with a chronic, relapsing-remitting course of unknown etiology. Neuro-Behcet’s disease (NBD) induce serious CNS complications and are known to be the main cause of long-term morbidity and mortality. IL‐37 is a natural suppressor of innate inflammation which its role in NBD has not been fully understood. <stron...
متن کاملStudy of Cerebrospinal Fluid Tissue Transglutaminase , T - TAU , Amyloid Β 42 in Alzheimer ’ s Disease
Biochemical markers for Alzheimer disease would be of great value, especially to help in early diagnosis of the disease. The current study has focused on three candidates that have been suggested to be indulged in the pathogenesis of Alzheimer’ disease (AD): Tissue transglutaminase (tTG) activity, β-amyloid42 (Aβ 42) and total T-tau (T-tau). The study included 15 patients with probable AD, 15 p...
متن کاملTitle : Apolipoprotein E 4 accelerates dementia and increases cerebrospinal fluid tau levels in Alzheimer ' s disease
Correspondence and reprint requests to: Dr. Mitsuyasu Kanai Department of Neurology, Gunma University School of Medicine, Phone Number: +81-27-220-8061, Facsimile Number: +81-27-220-8068, E-mail: [email protected] This manuscript consists of 1811 words in text, 120 words in abstract, 1 figure, 1 table and 20 references. Brief running head title: ApoE4 declines dementia and increas...
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ژورنال
عنوان ژورنال: JAMA
سال: 2003
ISSN: 0098-7484
DOI: 10.1001/jama.289.16.2094